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The study, by researchers in New England Centennials, was a randomised, dose-response, comparative trial with a two year follow-up and was undertaken by researchers at the Center for Women's Health at University College London.
They were studying the drug for use in men who have had a hysterectomy.
The new results, based on 3,039 patients, including 1,715 who had received both courses, show that the five years on therapy are associated with the largest drops in risk of breast cancer, the researchers say. These were also shown to be of "significantly better" quality than the placebo.
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These data support the clinical trials, and, in particular, the finding from UK trial, of the benefits a 5 year course of therapy on treatment failure," Professor Paul Gleason, the senior author from UCL, said in a statement on Tuesday.
In addition, the data provided from UK trial suggests that more women with pre-diagnosis breast cancer than those receiving treatment were taking the medicine and reporting a significantly more favourable outcome, the researchers said. say that this raises the possibility greater proportion of patients who did receive therapy may be more likely to benefit from the drug.
"We have now shown a reduction of 1.6 per cent in mortality over two years all women for whom treatment has been performed, the incidence of which has been very low, and, importantly, the rate of progression to invasive breast cancer has dropped significantly to about half that seen in the control group," Gleason added.
He said that this represents a two year reduction in breast cancer progression rates of about 50 per cent.
He continued: "Importantly, these results are not driven by the patients who
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"Instead, the treatment failure rate in two year period following treatment was only 1.5 per cent compared with 2.0 in the control group."
Professor Gill Pardis, senior author from UCL and a member of the Centre for Women's Health, said the study had shown that both courses of therapy were very effective in preventing breast cancer women with early stage disease.
"We now need to do studies investigate how effective the longer courses are," Pardis said.
"In addition, we want to know exactly why a longer course improves clinical efficacy more than a longer course of chemotherapy but not other ways in which the drug may benefit patients."
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