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Board
of Directors
Douglas
W. Lehrman
Mr.
Lehrman has served as Director since July 2000. Mr. Lehrman is
Managing Director at North Castle Partners, LLC in Greenwich,
Connecticut. For 17 years prior to founding North Castle with
his partners in 1998, Mr. Lehrman was an investment banker specializing
in leveraged buyouts. During that career he was involved
with over 50 transactions with a total value of approximately
$8 billion. Much of Mr. Lehrman's focus was developing new sources
of private capital for growth-oriented companies to achieve their
business plans. His focus at North Castle includes Grand Expeditions,
its global travel company, a variety of early stage investments
including Galileo Laboratories, and Healthnotes, in addition to
opportunities in the food, health information and other sectors.
Craig
C. Taylor
Mr.
Taylor has served as Director since January 1998. Mr. Taylor
is a General Partner of Alloy Ventures, formerly Asset Management,
and partner of AMC Partners 89, L.P. Mr. Taylor has been with
Asset Management, a venture management group, since 1977. Mr.
Taylor is currently a Director of Telor Ophthalmic Pharmaceuticals,
Inc., Metra BioSystems, Inc., Lynx Therapeutics, Inc., Pharmacyclics,
Inc. and of several private companies. Mr. Taylor holds BS and
MS degrees in physics from Brown University and an MBA from Stanford
University Graduate School of Business.
Roger
Salquist
Mr.
Salquist has served as Director since May 1999. Mr. Salquist is
a Partner and Managing Director of Bay City Capital ("BCC"),
a San Francisco-based merchant bank. BCC is the Advisor and Mr.
Salquist is the Chief Investment Officer of the North American
Nutrition and Agribusiness Fund, which invests in high-growth-potential
companies engaged in technological and business innovation in
the nutrition and agribusiness sectors. From 1984 through 1996,
Mr. Salquist served as Chairman and Chief Executive Officer of
Calgene, Inc. Mr. Salquist currently serves as a Director of Akkadix
Corporation, Lifespring, and OmegaTech, Inc. Mr. Salquist is a
trustee of the Fidelity Investments Charitable Gift Fund and a
member of the Board of Trustees of the University of San Francisco.
Mr. Salquist holds a BA and an MBA from Stanford University.
Richard
A. Miller, MD
Dr.
Miller has served as Director since January of 1998. Dr.
Miller is the President, Chief Executive Officer and a Director
of Pharmacyclics, Inc., a public biotechnology company, which
he co-founded in April 1991. In 1984, Dr. Miller co-founded IDEC
Pharmaceuticals Corporation, a public biotechnology company, where
he served as Vice President and a director until February 1992.
Dr. Miller also is Clinical Professor of Medicine (Oncology) at
Stanford University Medical Center. Dr. Miller received his MD,
summa cum laude, from the State University of New York
Medical School and is board certified in both Internal Medicine
and Medical Oncology.
Terry
Gould
Mr.
Gould has served as Director since January 1998. Mr. Gould is
Executive Director, Direct Investment Team at UBS Brinson. Prior
to joining UBS Brinson, Mr. Gould was with Trinity Ventures, Ltd.
Earlier in his career, Mr. Gould spent five years as a management
consultant, including at the Boston and San Francisco offices
of the Boston Consulting Group Inc., an international strategy-consulting
firm. Mr. Gould also was a founder of and manager in two successful,
entrepreneurial companies, Innovative Leisure and Viasoft. Mr.
Gould currently is a Director of Allegis Corporation (formerly
Net-It Software) and Network Integrity, Inc. Mr. Gould holds a
BA from Dartmouth College and an MBA from the Stanford University
Graduate School of Business.
Vicente
Anido, PhD
Dr.
Anido has served as Director since December 1998. Most recently
he served as Chief Executive Officer of CombiChem, Inc. Prior
to CombiChem, Inc., Dr. Anido was the President of the Americas
Region at Allergan, Inc., where he was responsible for the company's
commercial operations in North and South America. Prior to Allergan,
Dr. Anido spent approximately 18 years at Marion Laboratories
and Marion Merrell Dow. Dr. Anido holds BS and MS degrees in pharmacy
and pharmaceutical sciences from West Virginia University and
a PhD from the University of Missouri.
Guy
Miller, MD, PhD
Dr.
Miller, founder and Chief Executive Officer of Galileo Laboratories,
serves also as Chairman of the Board of Directors. Before forming
Galileo, Dr. Miller was Associate Professor at Johns Hopkins Medical
Institutions School of Medicine. After completing a Surgical Internship
at the University of Chicago, he completed a residency in Anesthesiology
& Critical Care Medicine and a Fellowship in Multidisciplinary
Critical Care Medicine at Johns Hopkins. Currently, Dr. Miller
is Clinical Instructor, Stanford University School of Medicine.
Dr. Miller holds an MD from the Medical College of Pennsylvania
and a PhD in Chemistry from the University of Virginia.
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Primary Outcome
The primary outcome measure was change in depression score obtained at baseline. Secondary outcomes included change in Hamilton Depression Rating Scale total score, change in Hamilton Rating Scale for Clinical Improvement (HRSD-C) total score, dropouts, and number of patients in the two groups.
The primary outcome measure at 2-week point was a 2-item scale (1=not at all, to 15=extremely) asking patients what they felt were helpful features and/or adverse effects of Sertraline. This survey was administered by trained and certified questionnaire takers who were unaware of trial allocation.
The drug store sodo seattle second survey was administered at the final baseline. Each patient was interviewed by two study investigators, who were blinded to trial group assignment. A score was obtained, which could be either 0 (not reporting any adverse effects) or 1 (reporting any adverse effects), from a Likert scale with minimum of 10 points. The investigators then calculated a standardized mean difference [SMD] from baseline in the two groups (0.2).
The trial was stopped early if either the primary or secondary outcomes failed to reach statistical significance.
Assessments
Determinations of patients randomized in the two groups were based on medical chart review, a completed computerized diagnostic interview, and/or a physician's interview with each patient the diagnosis of depression.
All patients, with age and baseline depression scores, were eligible for inclusion in the analysis. Patients with a history of drug dependence at baseline were excluded. characteristics summarized on the basis of patient self-report and interview data. Patients with concomitant psychotropic drug treatment were excluded.
The study protocol stipulated that each patient be followed for a minimum of 3 weeks. This time period was set through a computer-assisted telephone interview. Patients in both groups continued receiving their antidepressant treatment (ie, Sertraline injection 2 mg or placebo) during this time period. Additional information to guide the patient care was obtained from physicians, who conducted a medical chart review, completed interviews, and collected data Can you buy promethazine over the counter in the uk on all medications used.
Trial Outcomes
After completing the survey, participants were enrolled into a 2-week run-in period (ie, the time between study entry and the 3-week measurement of primary endpoint). Patients randomized to Sertraline injection were also encouraged to initiate Sertraline injection at 3 mg within to 4 weeks after randomization.
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At every visit for the 2 months after 2-week run-in period, the following items were completed to assure that no changes baseline characteristics, treatment assignment, medication, Online pharmacy clomid uk or health status existed during the 2 months:
1. Drug and alcohol abuse/dependence current medication use
At entry to the study, drug and alcohol abuse/dependence were assessed by physicians using the Structured Clinical Interview for DSM-IV axis I disorders (SCID). Participants who had recently been treated with an antidepressant or stimulant (as indicated by the presence or absence of a drug screen) prior to study entry had been added to the "recent antidepressant" category and were excluded.
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Valsartan generic for diovan alolone acetonide in chronic heart failure. Anticancer Res. 10, 1578–1584 (1987).
65. Fekadu-Anuar, D, O'Sullivan, J E and Thompson, F Jr: Diastolic pressure and blood response to high-dose aspirin and beta-blockers. JAMA 269, 1385–1389 (1984).
66. Shukla, R, Singh, A R and Chaudhry, U K.: Effect of β-blockers on serum potassium and urinary sodium in diabetic hypertension: is the relationship between potassium and sodium controlled? Diabetologia 29, 825–828 (1988).
67. Goyeneche, M I, Zaytoun, C and Douds, P T Jr: The effect of beta-blockers on insulin secretion and the renal function in patients with type 2 diabetes. Diabetes Care 13, 1587–1592 (1990).
68. Stolerman, J: The effect of drug therapy on plasma potassium. Diabetes Care 8, 1597–1602 (1980).
69. Tachir, K, Fiala, M and Sperlich, D: Effect of paracetamol treatment on potassium excretion in type 2 diabetic patients with hyperkalaemia. Diabetes Care 14, 927–931 (1981).
70. Stolerman, J: The effect of paracetamol on excretion potassium and the renal function schwietermans drug store inc new bremen united states in type 2 diabetic patients. Part I: Serum potassium. Diabetes Care 14, 1126–1128 (1981).
71. Fiala, M and Stolerman, J: Effect of paracetamol treatment on potassium excretion in type 2 diabetic patients with hyperkalaemia. Part II: Urinary excretion of potassium. Diabetes Care 14, 1197–1202 (1981).
72. Stolerman, J: The effects of paracetamol in hypokalaemic diabetic patients with hyperkalaemia: results of a randomized controlled is valsartan generic for diovan trial. Diabetes Care 12, 721–726 (1978).
73. Naughton, D and Gaughan, J: Blood-level study of the effect paracetamol and other anti-diabetic agents on the plasma concentration of potassium and salt. Diabetes 18, 1829–1838 (1982).
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