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Zoloft generic sertraline in buy zoloft online with prescription comparison to placebo were compared the results of meta-analysis, as reported in a recent meta-analysis published by Bélanger et al. [29], and Lefaucheur Haug et al. [30]. However, these meta-analyses included a very limited number of studies (only nine [11, 12] and only five controlled trials [12, 13]). Indeed, two other systematic reviews conducted from 2011 to 2013 also reported statistically significant improvements in the efficacy of Where can i buy cheap clomid pills different psychotherapies compared to placebo [24, 26]. However, Zoloft 90 Pills 50mg $95 - $1.06 Per pill this systematic review [24], included nine reviews (from 2004 to 2007) and nine studies that used different methodological approaches. Moreover, it failed to examine changes related time. Only one study [13] was conducted in adults [13]. Moreover, only one study [8] was conducted using a randomized controlled experimental design. The other four studies were of the more conservative observational design type (n = 11), using different outcome measures (disease severity and change in quality of life [26]). comparison, as noted above, these systematic reviews conducted from 2011 to 2013 reported statistically significant buy zoloft online cheap improvements in efficacy of different psychotherapies compared to placebo. The reasons for this discrepancy are not clear. Some investigators have argued that the positive results they obtained are not biologically plausible or clinically important [3], [31, 32], whereas other investigators have argued against this idea [33]. According to the authors of this systematic review [29], Bélanger et al. [29] compared only two studies that used different outcome measures (e.g., DAST) and they did not discuss psychobiological mechanisms such as the effect of antidepressants on neurotransmitters serotonin, nor dopamine. Bélanger et al. [29] also failed to mention the possible role of placebo effect. Another reason for the disagreement between two reviews [24, 26] could be Actoplus met xr coupon their different approaches. Whereas Bélanger et al. [24] used a more conservative approach, Haug et al. [30] used a more experimental approach, which could have led to a more significant result. In contrast, it has recently been argued from a clinical point of view that the effectiveness antidepressant drugs is dependent on the placebo effect [34]. clinical evidence for placebo effects on antidepressant-related outcome has been more controversial to date than that of the efficacy different psychotherapies. In this systematic review, we summarized the results of seven randomized controlled trials (RCTs) published in the last eight years. Furthermore, we performed meta-analysis to review studies published between 2003 and 2013 that reported statistically significant improvements compared with placebo and examined the changes corresponding to time. METHODS Search strategy We searched MEDLINE, EMBASE, CINAHL, Proquest, and PsycINFO, with our own hand-search, for studies published in English until January 2014 using several key terms (e.g., "antidepressant, antidepressants, placebo, fluoxetine") and combinations of those terms. In addition, we scanned the references of publications various authors, the included studies. Selecting studies To assess the validity and quality of data, we selected RCTs published in the last eight years, from database Cochrane of Systematic Reviews (CDBSR), Central Register of Controlled Trials, and Embase for systematic reviews [35]. the purpose of this search, studies were categorized as RCT if they were designed to test the effect of different psychotherapies (e.g., psychotherapy, psychoanalytic therapy, cognitive behavioral interpersonal or placebo) and used a clinical outcome measure that assessed the severity of depression. Furthermore, these studies were selected if they conducted in adults and had a minimum sample size of at least 75 participants [36]. For the purpose of systematic review, studies conducted with adults were not included [35]. We also conducted another search strategy using the following criteria: (1) clinical outcome measure used; (2) patients with depression and placebo control (i.e., not patients generic drug prices canada vs us without depression); (3) antidepressant, psychotherapy, and placebo groups were used; (4) the intervention consisted of one or more psychotherapies.